Gugulipid: A natural cholesterol-lowering agent

被引：179

作者：

Urizar, NL ^{[1
]}

Moore, DD ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

ANNUAL REVIEW OF NUTRITION | 2003年 / 23卷

关键词：

guggulsterone; FXR; ayurveda; Commiphora mukul;

D O I：

10.1146/annurev.nutr.23.011702.073102

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The resin of the Commiphora mukul tree has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments. Studies in both animal models and humans have shown that this resin, termed gum guggul, can decrease elevated lipid levels. The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin. Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regulator of cholesterol homeostasis. It is likely that this effect accounts for the hypolipidemic activity of these phytosteroids.

引用

页码：303 / 313

页数：11

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