Effect of low frequency AC electric fields on urokinase production by MPGN kidney cells

被引：10

作者：

Ellaiah, P ^{[1
]}

Saisha, V ^{[1
]}

Srinivasulu, B ^{[1
]}

机构：

[1] Andhra Univ, Dept Pharmaceut Sci, Pharmaceut Biotechnol Div, Waltair 530003, Andhra Pradesh, India

来源：

PROCESS BIOCHEMISTRY | 2003年 / 39卷 / 01期

关键词：

alternating current; field intensity; fibrin plate; glomerulo nephritis; urokinase; voltage;

D O I：

10.1016/S0032-9592(02)00295-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of a static electric field on the production of urokinase (UK) by AUB 101 cell line obtained from a kidney biopsy tissue of a mesangio proliferative glomerulo nephritic patient was studied. Cells were exposed to varying field intensities viz. 2.5-20 V and assayed for UK activity by a fibrin plate method. A gradual increase in UK activity was observed with increase in field strengths up to 10 V A. A maxima increase in UK production was observed in cells exposed to a electric field intensity of 10 V which amounts to 66% enhancement. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1 / 4

页数：4

共 18 条

[1]

ANDREI LK, 2000, BIOCHIM BIOPHYS ACTA, V1495, P90

[2]

Barlow G H, 1976, Methods Enzymol, V45, P239

[3]

BERNIK MB, 1967, J LAB CLIN MED, V70, P650

[4]

BICK RL, 1985, THROMBOLYTIC THERAPY