Mechanics of receptor-mediated endocytosis

被引:969
作者
Gao, HJ
Shi, WD
Freund, LB
机构
[1] Max Planck Inst Met Res, D-70569 Stuttgart, Germany
[2] Brown Univ, Div Engn, Providence, RI 02912 USA
关键词
cell adhesion; vesicle budding; virus; biomembrane; receptor-ligand binding;
D O I
10.1073/pnas.0503879102
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Most viruses and bioparticles enclocytosed by cells have characteristic sizes in the range of tens to hundreds of nanometers. The process of viruses entering and leaving animal cells is mediated by the binding interaction between ligand molecules on the viral capid and their receptor molecules on the cell membrane. How does the size of a bioparticle affect receptor-mediated enclocytosis? Here, we study how a cell membrane containing diffusive mobile receptors wraps around a ligand-coated cylindrical or spherical particle. It is shown that particles in the size range of tens to hundreds of nanometers can enter or exit cells via wrapping even in the absence of clathrin or caveolin coats, and an optimal particles size exists for the smallest wrapping time. This model can also be extended to include the effect of clathrin coat. The results seem to show broad agreement with experimental observations.
引用
收藏
页码:9469 / 9474
页数:6
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