Models of neuroendocrine prostate cancer

被引：40

作者：

Berman-Booty, Lisa D. ^{[1
,2
]}

Knudsen, Karen E. ^{[1
,2
,3
,4
]}

机构：

[1] Thomas Jefferson Univ, Dept Canc Biol, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[3] Thomas Jefferson Univ, Dept Urol, Philadelphia, PA 19107 USA

[4] Thomas Jefferson Univ, Dept Radiat Oncol, Philadelphia, PA 19107 USA

来源：

关键词：

neuroendocrine prostate cancer; castration-resistant prostate cancer; xenograft tumors; genetically engineered mice; SMALL-CELL-CARCINOMA; LARGE T-ANTIGEN; TRANSGENIC MOUSE MODEL; MOLECULAR CHARACTERIZATION; HISTOLOGICAL VARIANTS; ANDROGEN DEPRIVATION; DRUG DEVELOPMENT; XENOGRAFT MODEL; TRAMP MODEL; DIFFERENTIATION;

D O I：

10.1530/ERC-14-0393

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Prostate cancer remains the second leading cause of cancer death in men in the USA and most western countries. Prostatic acinar adenocarcinoma is the most commonly diagnosed form of prostate cancer. Small-cell neuroendocrine carcinoma is less frequently identified at the time of initial diagnosis, but this highly aggressive form of prostate cancer is increasingly observed in patients who have failed first- and second-line hormone therapy. Thus, developing and exploring models of neuroendocrine prostate cancer (NePC) are of increasing importance. This review examines the relevant xenograft tumor and genetically engineered mouse models of NePC, with the aim of addressing salient features and clinical relevance.

引用

页码：R33 / R49

页数：17

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