Fast protein folding on downhill energy landscape

被引：33

作者：

Cavalli, A ^{[1
]}

Haberthür, U ^{[1
]}

Paci, E ^{[1
]}

Caflisch, A ^{[1
]}

机构：

[1] Univ Zurich, Dept Biochem, CH-8057 Zurich, Switzerland

来源：

PROTEIN SCIENCE | 2003年 / 12卷 / 08期

关键词：

protein folding; Levinthal's paradox; molecular dynamics; unfolded state; beta-sheet; folding rate;

D O I：

10.1110/ps.0366103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteins fold in a time range of microseconds to minutes despite the large amount of possible conformers. Molecular dynamics simulations of a three-stranded antiparallel beta-sheet peptide (for a total of 12.6 musec and 72 folding events) show that at the melting temperature the unfolded state ensemble contains many more conformers than those sampled during a folding event.

引用

页码：1801 / 1803

页数：3

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