Blood vessels and nerves: Common signals, pathways and diseases

被引:410
作者
Carmeliet, P [1 ]
机构
[1] Katholieke Univ Leuven VIB, Ctr Transgene Technol & Gene Therapy, B-3000 Leuven, Belgium
关键词
D O I
10.1038/nrg1158
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Both blood vessels and nerves are vital channels to and from tissues. Recent genetic insights show that they have much more in common than was originally anticipated. They use similar signals and principles to differentiate, grow and navigate towards their targets. Moreover, the vascular and nervous systems cross-talk and, when dysregulated, this contributes to medically important diseases. The realization that both systems use common genetic pathways should not only form links between vascular biology and neuroscience, but also promises to accelerate the discovery of new mechanistic insights and therapeutic opportunities.
引用
收藏
页码:710 / 720
页数:11
相关论文
共 165 条
[1]   Glial-endothelial communication in physiology and pathology [J].
Abbot, NJ .
JOURNAL OF NEUROCHEMISTRY, 2003, 85 :2-2
[2]   Eph receptors and ephrin ligands: Essential mediators of vascular development [J].
Adams, RH ;
Klein, R .
TRENDS IN CARDIOVASCULAR MEDICINE, 2000, 10 (05) :183-188
[3]   The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration [J].
Adams, RH ;
Diella, F ;
Hennig, S ;
Helmbacher, F ;
Deutsch, U ;
Klein, R .
CELL, 2001, 104 (01) :57-69
[4]   Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis [J].
Adams, RH ;
Wilkinson, GA ;
Weiss, C ;
Diella, F ;
Gale, NW ;
Deutsch, U ;
Risau, W ;
Klein, R .
GENES & DEVELOPMENT, 1999, 13 (03) :295-306
[5]   Early induction of neural crest cells: lessons learned from frog, fish and chick [J].
Aybar, MJ ;
Mayor, R .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (04) :452-458
[6]   Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor [J].
Bagnard, D ;
Vaillant, C ;
Khuth, ST ;
Dufay, N ;
Lohrum, M ;
Püschel, AW ;
Belin, MF ;
Bolz, J ;
Thomasset, N .
JOURNAL OF NEUROSCIENCE, 2001, 21 (10) :3332-3341
[7]  
Bagri A, 2002, ADV EXP MED BIOL, V515, P13
[8]   Development - Endothelium - Chicken soup for the endoderm [J].
Bahary, N ;
Zon, LI .
SCIENCE, 2001, 294 (5542) :530-531
[9]   Induction of embryonic hematopoietic and endothelial stem/progenitor cells by hedgehog-mediated signals [J].
Baron, MH .
DIFFERENTIATION, 2001, 68 (4-5) :175-185
[10]   The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor [J].
Basu, S ;
Nagy, JA ;
Pal, S ;
Vasile, E ;
Eckelhoefer, IA ;
Bliss, VS ;
Manseau, EJ ;
Dasgupta, PS ;
Dvorak, HF ;
Mukhopadhyay, D .
NATURE MEDICINE, 2001, 7 (05) :569-574