The G protein β3 subunit 825T allele is a genetic marker for enhanced T cell response

被引：83

作者：

Lindemann, M

Virchow, S

Ramann, F

Barsegian, V

Kreuzfelder, E

Siffert, W

Müller, N

Grosse-Wilde, H ^{[1
]}

机构：

[1] Univ Essen Gesamthsch Klinikum, Inst Immunol, D-45122 Essen, Germany

[2] Univ Essen Gesamthsch Klinikum, Inst Pharmakol, D-45122 Essen, Germany

[3] Univ Essen Gesamthsch Klinikum, Inst Transfus Med, D-45122 Essen, Germany

来源：

FEBS LETTERS | 2001年 / 495卷 / 1-2期

关键词：

lymphocyte; proliferation; chemotaxis; CD4; G protein; genotype;

D O I：

10.1016/S0014-5793(01)02339-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The G protein beta3 subunit (GNB3) 825T allele is predictive of enhanced Gi protein activation. Studying the influence of C825T allele status on cellular in vitro immune responses towards recall antigens and interleukin-2 stimulation we observed a 2-4-fold, significantly increased proliferation in homozygous 825T (TT) vs. C825 allele (CC) carriers. Furthermore, lymphocyte chemotaxis and CD4(+) T cell counts of individuals with TT+TC genotypes H ere significantly enhanced compared to the CC genotype. In summary, it appears that C825T allele status is highly predictive of immunocompetence and could be a candidate gene in disorders associated,vith inadequate immune response. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：82 / 86

页数：5

共 24 条

[1] GENETIC-CONTROL OF THE CD4/CD8 T-CELL RATIO IN HUMANS [J].