Environmental modulation of anxiety-related neuronal activity and behaviors

被引：12

作者：

Bilkei-Gorzo, Andras ^{[1
]}

Otto, Martin ^{[1
]}

Zimmer, Andreas ^{[1
]}

机构：

[1] Univ Bonn, Inst Mol Psychiat, D-53125 Bonn, Germany

来源：

BEHAVIOURAL BRAIN RESEARCH | 2008年 / 186卷 / 02期

关键词：

anxiety behavior; environmental effect; c-fos; limbic system; preproenkephalin knockout; amphetamine;

D O I：

10.1016/j.bbr.2007.08.027

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Enkephalin-deficient knockout mice, a genetic model of enhanced anxiety responses, and wild-type controls were housed in two separate facilities on the same campus using different caging systems. Stress reactivity was evaluated in these animals using a zero-maze test followed by c-Fos expression analysis in limbic brain regions. Animals with genetically or pharmacologically enhanced anxiety reared and tested in the same facility displayed similar behavioral reactivity and c-Fos induction. However, we found much stronger anxiety-related behavioral responses and higher c-Fos levels when animals were house in individually ventilated cages, independent of their genetic background. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：289 / 292

页数：4

共 23 条

[1] Behavioral phenotype of pre-proenkephalin-deficient mice on diverse congenic backgrounds [J].

Bilkei-Gorzo, A ;

Racz, I ;

Michel, K ;

Zimmer, A ;

Klingmüller, D ;

Zimmer, A .

PSYCHOPHARMACOLOGY, 2004, 176 (3-4) :343-352

[2]

Bilkei-Gorzo A, 1996, Neurobiology (Bp), V4, P405

[3] Animal models - Can a mouse be standardized? [J].

Bohannon, J .

SCIENCE, 2002, 298 (5602) :2320-2321

[4] EMPReSS: standardized phenotype screens for functional annotation of the mouse genome [J].

Brown, SDM ;

Chambon, P ;

de Angelis, MH .

NATURE GENETICS, 2005, 37 (11) :1155-1155

[5] Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice [J].

Carola, V ;

D'Olimpio, F ;

Brunamonti, E ;

Mangia, F ;

Renzi, P .

BEHAVIOURAL BRAIN RESEARCH, 2002, 134 (1-2) :49-57

[6] Genetic basis of anxiety-like behaviour:: A critical review [J].

Clément, Y ;

Calatayud, F ;

Belzung, C .

BRAIN RESEARCH BULLETIN, 2002, 57 (01) :57-71

[7] Genetics of mouse behavior: Interactions with laboratory environment [J].

Crabbe, JC ;

Wahlsten, D ;

Dudek, BC .

SCIENCE, 1999, 284 (5420) :1670-1672

[8]

Crabbe JC, 2003, SCIENCE, V299, P1313

[9] Stress, genes and the mechanism of programming the brain for later life [J].

de Kloet, ER ;

Sibug, RM ;

Helmerhorst, FM ;

Schmidt, M .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2005, 29 (02) :271-281

[10] Stress-induced c-Fos expression is differentially modulated by dexamethasone, diazepam and imipramine [J].

de Medeiros, MA ;

Reis, LC ;

Mello, LE .

NEUROPSYCHOPHARMACOLOGY, 2005, 30 (07) :1246-1256

← 1 2 3 →