Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China

被引：1586

作者：

Guan, Y

Zheng, BJ

He, YQ

Liu, XL

Zhuang, ZX

Cheung, CL

Luo, SW

Li, PH

Zhang, LJ

Guan, YJ

Butt, KM

Wong, KL

Chan, KW

Lim, W

Shortridge, KF

Yuen, KY

Peiris, JSM

Poon, LLM

机构：

[1] Univ Hong Kong, Dept Microbiol, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China

[2] Ctr Dis Control & Prevent, Shenzhen, Guangdong Prov, Peoples R China

[3] Univ Hong Kong, Dept Pathol, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China

[4] Dept Hlth, Govt Virus Unit, Hong Kong, Hong Kong, Peoples R China

来源：

SCIENCE | 2003年 / 302卷 / 5643期

关键词：

D O I：

10.1126/science.1087139

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals ( including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.

引用

页码：276 / 278

页数：3

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