Inhibitory effects of the lichen metabolite lobaric acid on arachidonate metabolism in vitro

被引：33

作者：

Ingolfsdottir, K ^{[1
]}

Gissurarson, SR ^{[1
]}

MullerJakic, B ^{[1
]}

Breu, W ^{[1
]}

Wagner, H ^{[1
]}

机构：

[1] UNIV MUNICH,INST PHARMAZEUT BIOL,D-80333 MUNICH,GERMANY

来源：

PHYTOMEDICINE | 1996年 / 2卷 / 03期

关键词：

Stereocaulon alpinum; lichen; lobaric acid; 5-lipoxygenase; leukotriene synthesis; arachidonate metabolism;

D O I：

10.1016/S0944-7113(96)80049-3

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An extract containing phenolic constituents of the lichen Stereocaulon alpinum was shown to exhibit potent in vitro inhibitory effects on arachidonate 5-lipoxygenase from porcine leucocytes. The active component has been identified as the orcinol depsidone lobaric acid iii, which shows dose-dependent inhibitory effects on the enzyme, with an IC50 Value Of 7.3 mu M. Lobaric acid exhibits approximately 4-fold in vitro selectivity for 5-lipoxygenase as compared to cyclooxygenase.

引用

页码：243 / 246

页数：4

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