Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling

被引：49

作者：

Moro, S ^{[1
]}

Deflorian, F

Spalluto, G

Pastorin, G

Cacciari, B

Kim, SK

Jacobson, KA

机构：

[1] Univ Padua, Dept Pharmaceut Sci, Mol Modeling Sect, Padua, Italy

[2] Univ Trieste, Dept Pharmaceut Sci, Trieste, Italy

[3] Univ Ferrara, Dept Pharmaceut Sci, I-44100 Ferrara, Italy

[4] NIDDK, Mol Recognit Sect, LBC, NIH, Bethesda, MD USA

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 24期

关键词：

D O I：

10.1039/b303439a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We review our recent work on adenosine receptors, a family of GPCRs; focusing our attention on A(3) adenosine receptor, we have demonstrated that the reciprocal integration of different theoretical and experimental disciplines can be very useful for the successful protein-based design of new, potent and selective receptor ligands.

引用

页码：2949 / 2956

页数：8

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