Planarian homologs of netrin and netrin receptor are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture

被引:221
作者
Cebrià, F
Newmark, PA
机构
[1] Univ Illinois, Dept Cell & Dev Biol, Chem & Life Sci Lab, Urbana, IL 61801 USA
[2] Univ Illinois, Neurosci Program, Urbana, IL 61801 USA
来源
DEVELOPMENT | 2005年 / 132卷 / 16期
关键词
D O I
10.1242/dev.01941
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Conserved axon guidance mechanisms are essential for proper wiring of the nervous system during embryogenesis; however, the functions of these cues in adults and during regeneration remain poorly understood. Because freshwater planarians can regenerate a functional central nervous system (CNS) from almost any portion of their body, they are useful models in which to study the roles of guidance cues during neural regeneration. Here, we characterize two netrin homologs and one netrin receptor family member from Schmidtea mediterranea. RNAi analyses indicate that Smed-netR (netrin receptor) and Smed-netrin2 are required for proper CNS regeneration and that Smed-netR may mediate the response to Smed-netrin2. Remarkably, Smed-netR and Smed-netrin2 are also required in intact planarians to maintain the proper patterning of the CNS. These results suggest a crucial role for guidance cues, not only in CNS regeneration but also in maintenance of neural architecture.
引用
收藏
页码:3691 / 3703
页数:13
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