Synthesis of a cyclic diaryl ether derivative under solid-phase conditions

被引：11

作者：

Nakamura, K

Nishiya, H

Nishiyama, S

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

[2] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058566, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 36期

关键词：

isodityrosine; diaryl ether; thallium trinitrate; phenolic oxidation; solid-phase reaction;

D O I：

10.1016/S0040-4039(01)01240-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The TTN phenolic oxidation, along with the N-protective group of the corresponding tripeptide derivatives, was examined to accomplish construction of a cyclic isodityrosine derivative under solid-phase conditions. The desired cyclization was effected under the TTN (thallium(III) trinitrate)/NMP-MeOH conditions to give the corresponding 17-membered ring lactam 12. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6311 / 6313

页数：3

共 10 条

[1] A backbone linker for BOC-based peptide synthesis and on-resin cyclization: Synthesis of stylostatin 1 [J].