Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs

被引：82

作者：

Griffin, Brendan T. ^{[1
]}

Guo, Jianfeng ^{[1
]}

Presas, Elena ^{[1
]}

Donovan, Maria D. ^{[1
]}

Alonso, Maria J. ^{[2
]}

O'Driscoll, Caitriona M. ^{[1
]}

机构：

[1] Univ Coll Cork, Sch Pharm, Cavanagh Pharm Bldg, Cork, Ireland

[2] Univ Santiago Compostela, CIMUS Res Inst, Santiago De Compostela, Spain

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 106卷

关键词：

Pharmacokinetics and pharmacodynamics of peptide and protein drugs; Nanoparticles for oral administration; Bioavailability; Regulatory challenges; Physiologically-based pharmacokinetic modelling; SOLID LIPID NANOPARTICLES; IN-VIVO EVALUATION; PLGA NANOPARTICLES; CYCLOSPORINE-A; MUCOSAL IMMUNIZATION; SILICA NANOPARTICLES; HYDROPHILIC PEPTIDE; MODIFIED LIPOSOMES; PERORAL DELIVERY; NEXT-GENERATION;

D O I：

10.1016/j.addr.2016.06.006

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The influence of nanoparticle (NP) formulations on the pharmacokinetic, pharmacodynamic and biodistribution profiles of peptide- and protein-like drugs following oral administration is critically reviewed. The possible mechanisms of absorption enhancement and the effects of the physicochemical properties of the NP are examined. The potential advantages and challenges of physiologically-based pharmacokinetic (PBPK) modelling to help predict efficacy in man are discussed. The importance of developing and expanding the regulatory framework to help translate the technology into the clinic and accelerate the availability of oral nanoparticulate formulations is emphasized. In conclusion, opportunities for future work to improve the state of the art of oral nanomedicines are identified. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：367 / 380

页数：14

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