TNF and sTNFR1/2 plasma levels in ALS patients

被引：71

作者：

Cereda, Cristina ^{[1
]}

Baiocchi, Chiara ^{[2
]}

Bongioanni, Paolo ^{[3
]}

Cova, Emanuela ^{[1
]}

Guareschi, Stefania ^{[1
]}

Metelli, Maria Rita ^{[4
]}

Rossi, Bruno ^{[3
]}

Sbalsi, Ilaria ^{[2
]}

Cuccia, Maria Clara ^{[2
]}

Ceroni, Mauro ^{[1
,5
,6
]}

机构：

[1] IRCCS C Mondino, Neurol Inst, Pavia, Italy

[2] Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy

[3] Azienda Osped Univ Pisana, Unit Neurorehabil, Pisa, Italy

[4] Univ Pisa, Dept Expt Pathol, I-56100 Pisa, Italy

[5] Univ Pisa, Dept Neurol Sci, I-56100 Pisa, Italy

[6] Policlin Monza, Dept Neurol, Monza, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 194卷 / 1-2期

关键词：

TNF-alpha; TNF-R1; TNF-R2; amyotrophic lateral sclerosis; plasma;

D O I：

10.1016/j.jneuroim.2007.10.028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subjects. The genetic analysis of the polymorphisms of TNF-alpha, TNF-R1 and TNF-R2 showed no statistically significant differences in alleles and genotype frequencies between patients and controls. These data suggest a participation of the immune system in response to as far unknown intracellular signals. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：123 / 131

页数：9

共 49 条

[1] STABILIZATION OF THE BIOACTIVITY OF TUMOR-NECROSIS-FACTOR BY ITS SOLUBLE RECEPTORS [J].