On the mechanism of chorismate mutases: Clues from wild-type E-coli enzyme and a site-directed mutant related to yeast chorismate mutase

被引：29

作者：

Galopin, CC

Zhang, S

Wilson, DB

Ganem, B

机构：

[1] CORNELL UNIV,BAKER LAB,DEPT CHEM,ITHACA,NY 14853

[2] CORNELL UNIV,SECT BIOCHEM MOL & CELLULAR BIOL,ITHACA,NY 14853

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(96)02007-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thermodynamic parameters for E. coli chorismate mutase are reported. In addition, site-directed mutagenesis studies provide a direct mechanistic link to yeast chorismate mutase, further indicating the importance of entropic restriction and hydrogen bonding in the enzymic catalysis of Claisen rearrangements. Copyright (C) 1996 Elsevier Science Ltd

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页码：8675 / 8678

页数：4

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