Polymer-supported acylhydrazones.: Use in Sc(OTf)3-catalyzed Mannich-type reactions providing an efficient method for the preparation of diverse pyrazolone derivatives

被引：44

作者：

Kobayashi, S

Furuta, T

Sugita, K

Okitsu, O

Oyamada, H

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, CREST,Japan Sci & Technol Corp, Tokyo 1130033, Japan

[2] Sci Univ Tokyo, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 1620825, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(98)02607-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polymer-supported acylhydrazones, prepared from polystyrene resin (1%-divinylbenzene), reacted with ketene silyl acetals in the presence of a catalytic amount of scandium triflate (Sc(OTf)(3)), to afford the corresponding beta-hydrazinoesters, which were cyclized and cleaved from the support simultaneously by treatment with a base to produce diverse pyrazolone derivatives. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1341 / 1344

页数：4

共 17 条

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