共 53 条
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
被引:189
作者:

Kumamoto, Kensuke
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
Fukushima Med Univ, Sch Med, Dept Surg 2, Fukushima, Japan NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Spillare, Elisa A.
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Fujita, Kaori
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Horikawa, Izumi
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Yamashita, Taro
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Appella, Ettore
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Nagashima, Makoto
论文数: 0 引用数: 0
h-index: 0
机构:
Toho Univ, Sakura Hosp, Dept Surg, Sakura, Japan NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Takenoshita, Seiichi
论文数: 0 引用数: 0
h-index: 0
机构:
Fukushima Med Univ, Sch Med, Dept Surg 2, Fukushima, Japan NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Yokota, Jun
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Res Inst, Div Biol, Tokyo 104, Japan NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Harris, Curtis C.
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
机构:
[1] NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
[2] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
[3] Toho Univ, Sakura Hosp, Dept Surg, Sakura, Japan
[4] Fukushima Med Univ, Sch Med, Dept Surg 2, Fukushima, Japan
[5] Natl Canc Ctr, Res Inst, Div Biol, Tokyo 104, Japan
关键词:
D O I:
10.1158/0008-5472.CAN-07-2780
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Nutlin-3, an MDM2 inhibitor, activates p53, resulting in several types of cancer cells undergoing apoptosis. Although p53 is mutated or deleted in similar to 50%o of all cancers, p53 is still functionally active in the other 50%. Consequently, nutlin-3 and similar drugs could be candidates for neoadjuvant therapy in cancers with a functional p53. Cellular senescence is also a phenotype induced by p53 activation and plays a critical role in protecting against tumor development. In this report, we found that nutlin-3a can induce senescence in normal human fibroblasts. Nutlin-3a activated and repressed a large number of p53-dependent genes, including those encoding microRNAs. mir-34a, mir-34b, and mir-34c, which have recently been shown to be downstream effectors of p53-mediated senescence, were up-regulated, and inhibitor of growth 2 (ING2) expression was suppressed by nutlin-3a treatment. Two candidates for a p53-DNA binding consensus sequence were found in the ING2 promoter regulatory region; thus, we performed chromatin immunoprecipitation and electrophoretic mobility shift assays and confirmed p53 binding directly to those sites. In addition, the luciferase activity of a construct containing the ING2 regulatory region was repressed after p53 activation. Antisense knockdown of ING2 induces p53-independent senescence, whereas overexpression of ING2 induces p53-dependent senescence. Taken together, we conclude that nutlin-3a induces senescence through p53 activation in normal human fibroblasts, and p53-mediated mir34a, mir34b, and mir34c up-regulation and ING2 down-regulation may be involved in the senescence pathway.
引用
收藏
页码:3193 / 3203
页数:11
相关论文
共 53 条
[1]
Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1
[J].
Ambrosini, G.
;
Sambol, E. B.
;
Carvajal, D.
;
Vassilev, L. T.
;
Singer, S.
;
Schwartz, G. K.
.
ONCOGENE,
2007, 26 (24)
:3473-3481

Ambrosini, G.
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Dept Med, Lab New Drug Dev, New York, NY 10021 USA

Sambol, E. B.
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Dept Med, Lab New Drug Dev, New York, NY 10021 USA

Carvajal, D.
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Dept Med, Lab New Drug Dev, New York, NY 10021 USA

Vassilev, L. T.
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Dept Med, Lab New Drug Dev, New York, NY 10021 USA

Singer, S.
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Dept Med, Lab New Drug Dev, New York, NY 10021 USA

Schwartz, G. K.
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Dept Med, Lab New Drug Dev, New York, NY 10021 USA
[2]
OVEREXPRESSION OF CYCLIN D1 BLOCKS PROLIFERATION OF NORMAL DIPLOID FIBROBLASTS
[J].
ATADJA, P
;
WONG, H
;
VEILLETE, C
;
RIABOWOL, K
.
EXPERIMENTAL CELL RESEARCH,
1995, 217 (02)
:205-216

ATADJA, P
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALGARY, HLTH SCI CTR, DEPT MED BIOCHEM, CALGARY, AB 2N 4N1, CANADA

WONG, H
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALGARY, HLTH SCI CTR, DEPT MED BIOCHEM, CALGARY, AB 2N 4N1, CANADA

VEILLETE, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALGARY, HLTH SCI CTR, DEPT MED BIOCHEM, CALGARY, AB 2N 4N1, CANADA

RIABOWOL, K
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALGARY, HLTH SCI CTR, DEPT MED BIOCHEM, CALGARY, AB 2N 4N1, CANADA
[3]
Genomic maps and comparative analysis of histone modifications in human and mouse
[J].
Bernstein, BE
;
Kamal, M
;
Lindblad-Toh, K
;
Bekiranov, S
;
Bailey, DK
;
Huebert, DJ
;
McMahon, S
;
Karlsson, EK
;
Kulbokas, EJ
;
Gingeras, TR
;
Schreiber, SL
;
Lander, ES
.
CELL,
2005, 120 (02)
:169-181

Bernstein, BE
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

Kamal, M
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

Lindblad-Toh, K
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

Bekiranov, S
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

Bailey, DK
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

Huebert, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

论文数: 引用数:
h-index:
机构:

Karlsson, EK
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

Kulbokas, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

Gingeras, TR
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

Schreiber, SL
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

Lander, ES
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA
[4]
Oncogene-induced senescence: Putting the brakes on tumor development
[J].
Braig, M
;
Schmitt, CA
.
CANCER RESEARCH,
2006, 66 (06)
:2881-2884

Braig, M
论文数: 0 引用数: 0
h-index: 0
机构: Max Delbruck Ctr Mol Med, Berlin, Germany

Schmitt, CA
论文数: 0 引用数: 0
h-index: 0
机构: Max Delbruck Ctr Mol Med, Berlin, Germany
[5]
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
[J].
Chang, Tsung-Cheng
;
Wentzel, Erik A.
;
Kent, Oliver A.
;
Ramachandran, Kalyani
;
Mullendore, Michael
;
Lee, Kwang Hyuck
;
Feldmann, Georg
;
Yamakuchi, Munekazu
;
Ferlito, Marcella
;
Lowenstein, Charles J.
;
Arking, Dan E.
;
Beer, Michael A.
;
Maitra, Anirban
;
Mendell, Joshua T.
.
MOLECULAR CELL,
2007, 26 (05)
:745-752

Chang, Tsung-Cheng
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Wentzel, Erik A.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Kent, Oliver A.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Ramachandran, Kalyani
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Mullendore, Michael
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Lee, Kwang Hyuck
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Feldmann, Georg
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Yamakuchi, Munekazu
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Ferlito, Marcella
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Lowenstein, Charles J.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Arking, Dan E.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Beer, Michael A.
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Maitra, Anirban
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

Mendell, Joshua T.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA
[6]
MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells
[J].
Coll-Mulet, Llorenc
;
Iglesias-Serret, Daniel
;
Santidrian, Antonio F.
;
Cosialls, Ana M.
;
de Frias, Merce
;
Castano, Esther
;
Campas, Clara
;
Barragan, Montserrat
;
Fernandez de Sevilla, Alberto
;
Domingo, Alicia
;
Vassilev, Lyubomir T.
;
Pons, Gabriel
;
Gil, Joan
.
BLOOD,
2006, 107 (10)
:4109-4114

Coll-Mulet, Llorenc
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

Iglesias-Serret, Daniel
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

Santidrian, Antonio F.
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

Cosialls, Ana M.
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

de Frias, Merce
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

Castano, Esther
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

Campas, Clara
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

Barragan, Montserrat
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

Fernandez de Sevilla, Alberto
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

Domingo, Alicia
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

Vassilev, Lyubomir T.
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

Pons, Gabriel
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain

Gil, Joan
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Llobregat, Dept Clin Hematol, IDIBELL, Inst Catala Oncol, Barcelona, Spain
[7]
Tumour biology -: Senescence in premalignant tumours
[J].
Collado, M
;
Gil, J
;
Efeyan, A
;
Guerra, C
;
Schuhmacher, AJ
;
Barradas, M
;
Benguría, A
;
Zaballos, A
;
Flores, JM
;
Barbacid, M
;
Beach, D
;
Serrano, M
.
NATURE,
2005, 436 (7051)
:642-642

Collado, M
论文数: 0 引用数: 0
h-index: 0
机构:
CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain

论文数: 引用数:
h-index:
机构:

Efeyan, A
论文数: 0 引用数: 0
h-index: 0
机构: CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain

Guerra, C
论文数: 0 引用数: 0
h-index: 0
机构: CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain

Schuhmacher, AJ
论文数: 0 引用数: 0
h-index: 0
机构: CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain

Barradas, M
论文数: 0 引用数: 0
h-index: 0
机构: CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain

Benguría, A
论文数: 0 引用数: 0
h-index: 0
机构: CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain

Zaballos, A
论文数: 0 引用数: 0
h-index: 0
机构: CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain

Flores, JM
论文数: 0 引用数: 0
h-index: 0
机构: CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain

Barbacid, M
论文数: 0 引用数: 0
h-index: 0
机构: CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain

Beach, D
论文数: 0 引用数: 0
h-index: 0
机构: CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain

Serrano, M
论文数: 0 引用数: 0
h-index: 0
机构: CNIO, Spanish Natl Canc Ctr, Madrid 28029, Spain
[8]
Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers
[J].
Craig, AL
;
Burch, L
;
Vojtesek, B
;
Mikutowska, J
;
Thompson, A
;
Hupp, TR
.
BIOCHEMICAL JOURNAL,
1999, 342
:133-141

Craig, AL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland

Burch, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland

Vojtesek, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland

Mikutowska, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland

Thompson, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland

Hupp, TR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Dundee, Ninewells Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland Univ Dundee, Ninewells Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland
[9]
A BIOMARKER THAT IDENTIFIES SENESCENT HUMAN-CELLS IN CULTURE AND IN AGING SKIN IN-VIVO
[J].
DIMRI, GP
;
LEE, XH
;
BASILE, G
;
ACOSTA, M
;
SCOTT, C
;
ROSKELLEY, C
;
MEDRANO, EE
;
LINSKENS, M
;
RUBELJ, I
;
PEREIRASMITH, O
;
PEACOCKE, M
;
CAMPISI, J
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1995, 92 (20)
:9363-9367

DIMRI, GP
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720

LEE, XH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720

BASILE, G
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720

ACOSTA, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720

SCOTT, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720

ROSKELLEY, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720

MEDRANO, EE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720

LINSKENS, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720

RUBELJ, I
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720

PEREIRASMITH, O
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720

PEACOCKE, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720

CAMPISI, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF BERKELEY,DEPT CELL & MOLEC BIOL,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720
[10]
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation
[J].
Doyon, Y
;
Cayrou, C
;
Ullah, M
;
Landry, AJ
;
Côté, V
;
Selleck, W
;
Lane, WS
;
Tan, S
;
Yang, XJ
;
Côté, J
.
MOLECULAR CELL,
2006, 21 (01)
:51-64

Doyon, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Laval, Hotel Dieu, CHUQ, Canc Res Ctr, Quebec City, PQ G1R 2J6, Canada

Cayrou, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Laval, Hotel Dieu, CHUQ, Canc Res Ctr, Quebec City, PQ G1R 2J6, Canada

Ullah, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Laval, Hotel Dieu, CHUQ, Canc Res Ctr, Quebec City, PQ G1R 2J6, Canada

Landry, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Laval, Hotel Dieu, CHUQ, Canc Res Ctr, Quebec City, PQ G1R 2J6, Canada

Côté, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Laval, Hotel Dieu, CHUQ, Canc Res Ctr, Quebec City, PQ G1R 2J6, Canada

Selleck, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ Laval, Hotel Dieu, CHUQ, Canc Res Ctr, Quebec City, PQ G1R 2J6, Canada

Lane, WS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Laval, Hotel Dieu, CHUQ, Canc Res Ctr, Quebec City, PQ G1R 2J6, Canada

Tan, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Laval, Hotel Dieu, CHUQ, Canc Res Ctr, Quebec City, PQ G1R 2J6, Canada

Yang, XJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Laval, Hotel Dieu, CHUQ, Canc Res Ctr, Quebec City, PQ G1R 2J6, Canada

Côté, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Laval, Hotel Dieu, CHUQ, Canc Res Ctr, Quebec City, PQ G1R 2J6, Canada