Both pre- and posttraining excitotoxic lesions of the basolateral amygdala abolish the expression of olfactory and contextual fear conditioning

被引:124
作者
Cousens, G [1 ]
Otto, T [1 ]
机构
[1] Rutgers State Univ, Dept Psychol, Program Biopsychol & Behav Neurosci, New Brunswick, NJ 08903 USA
关键词
D O I
10.1037/0735-7044.112.5.1092
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The present study examined whether the basolateral amygdaloid complex (BLA) participates in the expression of fear conditioned to both an olfactory conditioned stimulus (CS) and the training context, In Experiment 1, pretraining excitotoxic lesions of the BLA abolished immediate postshock freezing, conditioned freezing to an olfactory CS, and conditioned freezing to the training context. Control experiments indicated that lesioned and sham-lesioned subjects did not differ in locomotor activity or in acquisition of a successive-cue odor discrimination task, suggesting that deficits in freezing behavior exhibited by BLA subjects were not due to an impairment in primary aspects of olfaction or to a general enhancement of locomotor activity. In Experiment 2, excitotoxic lesions of the BLA produced either 1 day or 15 days after olfactory fear conditioning abolished both odor-elicited and contextual freezing. Collectively, these data support the notion that the BLA participates in an enduring manner in the expression of conditioned freezing behavior elicited by both olfactory and contextual stimuli.
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页码:1092 / 1103
页数:12
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共 47 条
[1]  
BOLLES RC, 1970, PSYCHOL REV, V71, P31
[2]   Perirhinal and postrhinal cortices of the rat: A review of the neuroanatomical literature and comparison with findings from the monkey brain [J].
Burwell, RD ;
Witter, MP ;
Amaral, DG .
HIPPOCAMPUS, 1995, 5 (05) :390-408
[3]  
BURWELL RD, IN PRESS J COMP NEUR
[4]   INVOLVEMENT OF THE AMYGDALA IN STIMULUS REWARD ASSOCIATIONS - INTERACTION WITH THE VENTRAL STRIATUM [J].
CADOR, M ;
ROBBINS, TW ;
EVERITT, BJ .
NEUROSCIENCE, 1989, 30 (01) :77-86
[5]   Mechanisms of emotional arousal and lasting declarative memory [J].
Cahill, L ;
McGaugh, JL .
TRENDS IN NEUROSCIENCES, 1998, 21 (07) :294-299
[6]  
CAHILL L, 1990, BEHAV NEUROSCI, V104, P452
[7]   INTRAAMYGDALA INFUSION OF THE N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST AP5 BLOCKS ACQUISITION BUT NOT EXPRESSION OF FEAR-POTENTIATED STARTLE TO AN AUDITORY CONDITIONED-STIMULUS [J].
CAMPEAU, S ;
MISERENDINO, MJD ;
DAVIS, M .
BEHAVIORAL NEUROSCIENCE, 1992, 106 (03) :569-574
[8]  
DAVIS M, 1992, ANNU REV NEUROSCI, V15, P353, DOI 10.1146/annurev.ne.15.030192.002033
[9]  
De Olmos J.S., 1985, RAT NERVOUS SYSTEM, V1, P223
[10]  
EICHENBAUM H, 1986, J NEUROSCI, V6, P1876