Defective activation-induced cell death in NOD T lymphocytes -: 1,25-dihydroxyvitamin D3 restores defect

被引：3

作者：

DeCallonne, B ^{[1
]}

Mathieu, C ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Lab Expt Geneeskunde Endocrinol, B-3000 Louvain, Belgium

来源：

IMMUNOLOGY OF DIABETES II: PATHOGENESIS FROM MOUSE TO MAN | 2003年 / 1005卷

关键词：

activation-induced cell death (AICD); 1; alpha; 25-dihydroxyvitamin D-3 [1 alpha; 25(OH)(2)D-3; apoptosis resistance; T lymphocytes;

D O I：

10.1196/annals.1288.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was first to analyze strain differences in apoptosis resistance of NOD peripheral T lymphocytes in in vitro models of death by neglect and activation-induced cell death (AICD). Especially AICD is known to play a key role in peripheral tolerance, keeping autoimmune effector cells under control. Second, we studied the effects of in vivo treatment of NOD mice with 1alpha,25-dihydroxyvitamin D-3 [1alpha,25(OH)(2)D-3], an immunomodulator known to prevent diabetes and insulitis in NOD mice, on in vitro T lymphocyte apoptosis resistance.

引用

页码：176 / 177

页数：2

共 7 条

[1] Sex difference in resistance to dexamethasone-induced apoptosis in NOD mice treatment with 1,25(OH)2D3 restores defect [J].

Casteels, KM ;

Gysemans, CA ;

Waer, M ;

Bouillon, R ;

Laureys, JM ;

Depovere, J ;

Mathieu, C .

DIABETES, 1998, 47 (07) :1033-1037

[2] Programmed cell death in the pathogenesis of murine IDDM: Resistance to apoptosis induced in lymphocytes by cyclophosphamide [J].

Colucci, F ;

Cilio, CM ;

Lejon, K ;

Goncalves, CP ;

Bergman, ML ;

Holmberg, D .

JOURNAL OF AUTOIMMUNITY, 1996, 9 (02) :271-276

[3] A defect in central tolerance in NOD mice [J].

Kishimoto, H ;

Sprent, J .

NATURE IMMUNOLOGY, 2001, 2 (11) :1025-1031

[4] 1,25-DIHYDROXYVITAMIN-D3 PREVENTS INSULITIS IN NOD MICE [J].

MATHIEU, C ;

LAUREYS, J ;

SOBIS, H ;

VANDEPUTTE, M ;

WAER, M ;

BOUILLON, R .

DIABETES, 1992, 41 (11) :1491-1495

[5] PREVENTION OF AUTOIMMUNE DIABETES IN NOD MICE BY 1,25-DIHYDROXYVITAMIN-D-3 [J].

MATHIEU, C ;

WAER, M ;

LAUREYS, J ;

RUTGEERTS, O ;

BOUILLON, R .

DIABETOLOGIA, 1994, 37 (06) :552-558

[6] Splenic dendritic cells from the non-obese diabetic mouse induce a prolonged proliferation of syngeneic T cells. A role for an impaired apoptosis of NOD T cells? [J].

Radosevic, K ;

Casteels, KM ;

Mathieu, C ;

van Ewijk, W ;

Drexhage, HA ;

Leenen, PJM .

JOURNAL OF AUTOIMMUNITY, 1999, 13 (04) :373-382

[7]

Van Parijs L, 1998, SCIENCE, V280, P243

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