Genetics of allergen-induced asthma

被引:14
作者
Daser, A
Daheshia, M
De Sanctis, GT
机构
[1] Charite, Inst Lab Med & Pathobiochem, Berlin, Germany
[2] Brigham & Womens Hosp, Dept Rheumatol Immunol & Allergy, Boston, MA 02115 USA
[3] Brigham & Womens Hosp, Dept Med, Div Pulm, Boston, MA 02115 USA
[4] Brigham & Womens Hosp, Dept Med, Crit Care Div, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Boston, MA USA
关键词
airway hyperresponsiveness; antigen; asthma; genetics; inflammation; linkage;
D O I
10.1067/mai.2001.116987
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Antigen-induced airway hyperresponsiveness and airway inflammation are features of both human asthma and animal models of this disease. The genesis of these key asthma phenotypes represents the summation of a complex cascade of immune responses. It is hypothesized that multiple cell types are involved in the induction, propagation, and maintenance of these immune processes. Several molecules have been reported to be essential for cell-cell interactions, inflammatory cell recruitment; and effector functions leading to the overall expression of the asthmatic phenotype. This review summarizes the genetic evidence supporting a role for these molecules in antigen-driven airway hyperresponsiveness and inflammation.
引用
收藏
页码:167 / 174
页数:8
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