Central nervous system pericytes in health and disease

被引：748

作者：

Winkler, Ethan A. ^{[1
]}

Bell, Robert D. ^{[1
]}

Zlokovic, Berislav V. ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Neurol & Neurosurg, Ctr Neurodegenerat & Vasc Brain Disorders, Rochester, NY 14642 USA

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 11期

基金：

美国国家卫生研究院;

关键词：

BLOOD-BRAIN-BARRIER; SMOOTH-MUSCLE-CELLS; PDGF BETA-RECEPTOR; ALZHEIMERS-DISEASE; DIABETIC-RETINOPATHY; TGF-BETA; BONE-MARROW; N-CADHERIN; ENDOTHELIAL SURVIVAL; FUNCTIONAL HYPEREMIA;

D O I：

10.1038/nn.2946

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pericytes are uniquely positioned within the neurovascular unit to serve as vital integrators, coordinators and effectors of many neurovascular functions, including angiogenesis, blood-brain barrier (BBB) formation and maintenance, vascular stability and angioarchitecture, regulation of capillary blood flow and clearance of toxic cellular byproducts necessary for proper CNS homeostasis and neuronal function. New studies have revealed that pericyte deficiency in the CNS leads to BBB breakdown and brain hypoperfusion resulting in secondary neurodegenerative changes. Here we review recent progress in understanding the biology of CNS pericytes and their role in health and disease.

引用

页码：1398 / 1405

页数：8

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