The transition from hyperplasia to invasive carcinoma of the breast

被引：27

作者：

Lakhani, SR ^{[1
]}

机构：

[1] Univ London Univ Coll, Sch Med, Dept Histopathol, London WC1E 6JJ, England

来源：

JOURNAL OF PATHOLOGY | 1999年 / 187卷 / 03期

关键词：

breast; preinvasive lesions; molecular genetics; multistep model; loss of heterozygosity; comparative genomic hybridization;

D O I：

10.1002/(SICI)1096-9896(199902)187:3<272::AID-PATH265>3.0.CO;2-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The multistep model of carcinogenesis in the breast suggests a transition from normal epithelium to invasive carcinoma via non-atypical and atypical hyperplasia and in situ carcinoma, Within the breast, these proliferations are heterogeneous in their cytological and architectural characteristics. This review considers the evidence supporting a precursor role for these preinvasive lesions, Copyright (C) 1999 John Wiley & Sons, Ltd.

引用

页码：272 / 278

页数：7

共 92 条

[1]

ALDAZ CM, 1995, CANCER RES, V55, P3976

[2]

IMMUNOHISTOCHEMICAL STUDIES OF EARLY BREAST-CANCER EVOLUTION [J].

ALLRED, DC ;

OCONNELL, P ;

FUQUA, SAW ;

OSBORNE, CK .

BREAST CANCER RESEARCH AND TREATMENT, 1994, 32 (01) :13-18

[3]

OVEREXPRESSION OF HER-2 NEU AND ITS RELATIONSHIP WITH OTHER PROGNOSTIC FACTORS CHANGE DURING THE PROGRESSION OF INSITU TO INVASIVE BREAST-CANCER [J].

ALLRED, DC ;

CLARK, GM ;

MOLINA, R ;

TANDON, AK ;

SCHNITT, SJ ;

GILCHRIST, KW ;

OSBORNE, CK ;

TORMEY, DC ;

MCGUIRE, WL .

HUMAN PATHOLOGY, 1992, 23 (09) :974-979

[4]

BARTEK J, 1991, ONCOGENE, V6, P1699

[5]

BERGER MS, 1988, CANCER RES, V48, P1238

[6]

E-cadherin is a tumour invasion suppressor gene mutated in human lobular breast cancers [J].

Berx, G ;

CletonJansen, AM ;

Nollet, F ;

deLeeuw, WJF ;

vandeVijver, MJ ;

Cornelisse, C ;

vanRoy, F .

EMBO JOURNAL, 1995, 14 (24) :6107-6115

[7]

INTRADUCTAL CARCINOMA - LONG-TERM FOLLOW-UP AFTER TREATMENT BY BIOPSY ALONE [J].

BETSILL, WL ;

ROSEN, PP ;

LIEBERMAN, PH ;

ROBBINS, GF .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1978, 239 (18) :1863-1867

[8]

BLACK MM, 1972, CANCER, V29, P338, DOI 10.1002/1097-0142(197202)29:2&lt

[9]

338::AID-CNCR2820290212&gt

[10]

3.0.CO

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