FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome

被引：81

作者：

Attaoua, Redha ^{[1
]}

El Mkadem, Samira Ait ^{[1
]}

Radian, Serban ^{[2
]}

Fica, Simona ^{[2
]}

Hanzu, Felicia ^{[2
]}

Albu, Alice ^{[2
]}

Gheorghiu, Monica ^{[2
]}

Coculescu, Mihai ^{[2
]}

Grigorescu, Florin ^{[1
]}

机构：

[1] IURC, Mol Endocrinol Lab, F-34093 Montpellier 5, France

[2] Univ Med & Pharm Carol Davila, Dept Endocrinol, Bucharest, Romania

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 373卷 / 02期

关键词：

FTO gene; metabolic syndrome; polycystic ovary; single nuclectide polymorphism; haplotype; obesity; insulin resistance; genetic association; body mass index; glucose intolerance;

D O I：

10.1016/j.bbrc.2008.06.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The FTO (Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans. To understand the role of the FTO gene in polycystic ovary syndrome (PCOS) we genotyped single nucleotide polymorphism (SNP) rs1421085 (C/T) in women with PCOS (n = 207) and controls (n = 100) from a Central European population. The homozygous C/C genotype showed increased prevalence in PCOS patients either obese or with metabolic syndrome (MetS) compared to lean PCOS patients or controls (27.6%, 38.9%, 22.3%, and 16.3%, respectively). In logistic regression, this genotype strongly associated with MetS (P < 0.0001, OR 3.2, 95% CI 1.8-5.7) and impaired fasting glucose (IFG) with P < 0.0007, OR 7.7, 95% CI 2.1-28.6, independently of BMI or age, and to AUC(gluc) during OGTT (P < 0.0001, alpha = 0.99), indicating an influential role of the FTO gene in the glucose intolerance component of MetS. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：230 / 234

页数：5

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