IL-10 expression is associated with the expression of platelet-derived endothelial cell growth factor and prognosis in oral and oropharyngeal carcinoma

被引：39

作者：

Fujieda, S ^{[1
]}

Sunaga, H ^{[1
]}

Tsuzuki, H ^{[1
]}

Fan, GK ^{[1
]}

Saito, H ^{[1
]}

机构：

[1] Fukui Med Univ, Dept Otorhinolaryngol, Fukui 9101193, Japan

来源：

CANCER LETTERS | 1999年 / 136卷 / 01期

关键词：

IL-10; PD-ECGF; prognosis; head and neck cancer;

D O I：

10.1016/S0304-3835(98)00281-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the expression of IL-10 in oral and oropharyngeal squamous cell carcinoma (SCC) specimens by an immunohistochemical technique. Of 58 SCC, 13 (22%) and 35 (60%) cases showed intense and moderate positive staining of IL-10, respectively. There was no association between the staining of IL-10 and clinicopathological features. However, the patients with intense staining of IL-10 had a significantly lower overall survival rate than those with moderate or negative staining of IL-10 (P = 0.019). In addition, the patients with intense staining of IL-10 had the highest score of platelet-derived endothelial cell growth factor (PD-ECGF), which is established as a poor prognostic indicator (P = 0.0105). These results suggested that IL-10 contributes to the clinical outcome of oral and oropharyngeal SCC. (C) 1999 Elsevier Science ireland Ltd. All rights reserved.

引用

页码：1 / 9

页数：9

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