Influence of central antitussive drugs on the cough motor pattern

被引:85
作者
Bolser, DC
Hey, JA
Chapman, RW
机构
[1] Univ Florida, Dept Physiol Sci, Coll Vet Med, Gainesville, FL 32606 USA
[2] Allergy Schering Plough Res Inst, Kenilworth, NJ 07033 USA
关键词
diaphragm; abdominal; rectus abdominis; brain stem; control of breathing;
D O I
10.1152/jappl.1999.86.3.1017
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The present study was conducted to determine the effects of administration of centrally active antitussive drugs on the cough motor pattern. Electromyograms of diaphragm and rectus abdominis muscles were recorded in anesthetized, spontaneously breathing cats. Cough was produced by mechanical stimulation of the intrathoracic trachea. Centrally acting drugs administered included codeine, morphine, dextromethorphan, baclofen, CP-99,994, and SR-48,968. Intravertebral artery administration of all drugs reduced cough number (number of coughs per stimulus trial) and rectus abdominis burst amplitude in a dose-dependent manner. Codeine, dextromethorphan, CP-99,994, SR-48,968, and baclofen had no effect on cough cycle timing (CTtot) or diaphragm amplitude during cough, even at doses that inhibited cough number by 80-90%. Morphine lengthened CTtot and inhibited diaphragm amplitude during cough, but these effects were not dose dependent. Only CP-99,994 altered the eupneic respiratory pattern. Central antitussive drugs primarily suppress cough by inhibition of expiratory motor drive and cough number. CTtot and inspiratory motor drive are relatively insensitive to the effects of these drugs. CTtot can be controlled independently from cough number.
引用
收藏
页码:1017 / 1024
页数:8
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