Synthesis and properties of poly(L-lactide)-poly (ethylene glycol) multiblock copolymers by coupling triblock copolymers

被引:48
作者
Chen, WN [1 ]
Luo, WJ [1 ]
Wang, SG [1 ]
Bei, JZ [1 ]
机构
[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
关键词
poly(L-lactide); poly(ethylene glycol); multiblock copolymer; drug-controlled release; 5-fluorourecil;
D O I
10.1002/pat.301
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A series of multiblock copolymers of PLLA/PEG(PLE) with high molecular weight were synthesized by coupling PLLA-PEG-PLLA triblock copolymers with succinic anhydride in the presence of N-dimethylaminopyridine (DMAP) and dicyclohexylcarbodimide (DCC). The results of the viscometry measurement, GPC and H-1 NMR, elucidated that multiblock PLE copolymers with high content of short PEG segments had been successfully obtained. The thermal properties and the crystallinity were investigated by DSC and X-ray diffraction. Men LA/EG molar ratio and the length of PEG segments were the same in both multiblock and triblock copolymers, multiblock copolymers were less crystalline than the corresponding triblock ones. Mechanical testing showed that multiblock copolymers had relatively high tensile strength and large elongation. In a word, the measurements showed that this multiblock PLE copolymers had high content of short PEG segments (Mn = 2000,4000), high molecular weight (Mw similar to 50000), high hydrophilicity, and good mechanical properties. The drug (5-Fluorourecil) release behavior of these PLE multiblock copolymers had been studied in 0.10 M pH 7.4 phosphate buffer solution (PBS), and the releasing rate could be tailored by adjusting copolymers composition. All of these results indicated that the multiblock PLE copolymers might be useful in medical applications. Copyright (C) 2003 John Wiley Sons, Ltd.
引用
收藏
页码:245 / 253
页数:9
相关论文
共 21 条
[1]   Biodegradable amphiphilic multiblock copolymers and their implications for biomedical applications [J].
Bae, YH ;
Huh, KM ;
Kim, Y ;
Park, KH .
JOURNAL OF CONTROLLED RELEASE, 2000, 64 (1-3) :3-13
[2]   Relationship among drug delivery behavior, degradation behavior and morphology of copolylactones derived from glycolide, L-lactide and ε-caprolactone [J].
Cai, Q ;
Bei, JZ ;
Wang, SG .
POLYMERS FOR ADVANCED TECHNOLOGIES, 2002, 13 (02) :105-111
[3]  
CERRAI P, 1993, MAKROMOL CHEM-RAPID, V14, P529
[4]   Synthesis and characterization of [L]-lactide - Ethylene oxide multiblock copolymers [J].
Chen, XH ;
McCarthy, SP ;
Gross, RA .
MACROMOLECULES, 1997, 30 (15) :4295-4301
[5]  
Hakkarainen M, 2000, J APPL POLYM SCI, V76, P228, DOI 10.1002/(SICI)1097-4628(20000411)76:2<228::AID-APP12>3.0.CO
[6]  
2-B
[7]  
Hassner A, 1978, TETRAHEDRON LETT, V46, P4475
[8]   Synthesis and characterization of poly(ethylene glycol)/poly(L-lactic acid) alternating multiblock copolymers [J].
Huh, KM ;
Bae, YH .
POLYMER, 1999, 40 (22) :6147-6155
[9]  
JEDLINSKI Z, 1993, MAKROMOL CHEM, V194, P1681
[10]  
KRICHELDORF HR, 1986, MAKROMOL CHEM, V187, P1611