Simple and efficient TiCl4-mediated synthesis of biaryls via arylmagnesium compounds

被引:45
作者
Inoue, A [1 ]
Kitagawa, K [1 ]
Shinokubo, H [1 ]
Oshima, K [1 ]
机构
[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Sakyo Ku, Kyoto 6068501, Japan
关键词
biaryls; coupling reactions; titanium(IV) chloride; arylmagnesium compound; aryl halides;
D O I
10.1016/S0040-4020(00)00929-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Oxidative self-coupling reactions of various arylmagnesium bromides with TiCl4 affords the corresponding symmetric biaryls in moderate to good yields at 0 degreesC or lower. Tributylmagnesate-induced halogen-magnesium exchange of aryl halides followed by the coupling reaction provides biarlys in good yields under mild conditions. This method can achieve a one-pot synthesis of biaryls containing functional groups such as esters, amides, or nitriles. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:9601 / 9605
页数:5
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