Guanine, pyrazolo[3,4-d] pyrimidine, and triazolo[4,5-d] pyrimidine (8-azaguanine) phosphonate acyclic derivatives as inhibitors of purine nucleoside phosphorylase

被引：30

作者：

Beauchamp, LM ^{[1
]}

Tuttle, JV ^{[1
]}

Rodriguez, ME ^{[1
]}

Sznaidman, ML ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO,DIV EXPTL THERAPY,RES TRIANGLE PK,NC 27709

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 04期

关键词：

D O I：

10.1021/jm950736k

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phosphonate acyclic derivatives of guanines, pyrazolo[3,4-d]pyrimidines, and triazolo[4,5-d]-pyrimidines (8-azaguanines) are inhibitors of the enzyme purine nucleoside phosphorylase (PNPase) with K-i' values ranging from 0.05 to 1.6 mu M. These compounds are enzymatically stable congeners of the potent PNPase inhibitor acyclovir diphosphate (53).

引用

页码：949 / 956

页数：8

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