Exercise Attenuates the Major Hallmarks of Aging

被引：305

作者：

Garatachea, Nuria ^{[1
,2
,3
]}

Pareja-Galeano, Helios ^{[2
,4
]}

Sanchis-Gomar, Fabian ^{[2
]}

Santos-Lozano, Alejandro ^{[2
]}

Fiuza-Luces, Carmen ^{[2
,4
]}

Moran, Maria ^{[2
,5
]}

Emanuele, Enzo ^{[6
]}

Joyner, Michael J. ^{[7
]}

Lucia, Alejandro ^{[2
,4
]}

机构：

[1] Univ Zaragoza, Fac Hlth & Sport Sci, Huesca, Spain

[2] Hosp Univ 12 Octubre, Res Inst I 12, Mitochondrial & Neuromuscular Dis Lab, Madrid, Spain

[3] Univ Zaragoza, GENUD Growth Exercise Nutr & Dev Res Grp, Zaragoza, Spain

[4] European Univ Madrid, Madrid, Spain

[5] CIBER Enfermedades Raras, Madrid, Spain

[6] Univ Pavia, Dept Hlth Sci, I-27100 Pavia, Italy

[7] Mayo Clin, Dept Anesthesiol, Rochester, MN USA

来源：

REJUVENATION RESEARCH | 2015年 / 18卷 / 01期

关键词：

ACTIVATED PROTEIN-KINASE; MITOCHONDRIAL-DNA-DELETION; LEUKEMIA INHIBITORY FACTOR; HUMAN SKELETAL-MUSCLE; HEAVY-RESISTANCE EXERCISE; LONG-TERM POTENTIATION; SATELLITE CELL CONTENT; ENDOTHELIAL PROGENITOR CELLS; OXIDATIVE STRESS HYPOTHESIS; RANDOMIZED CONTROLLED TRIAL;

D O I：

10.1089/rej.2014.1623

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Regular exercise has multi-system anti-aging effects. Here we summarize how exercise impacts the major hallmarks of aging. We propose that, besides searching for novel pharmaceutical targets of the aging process, more research efforts should be devoted to gaining insights into the molecular mediators of the benefits of exercise and to implement effective exercise interventions for elderly people.

引用

页码：57 / 89

页数：33

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