Immunology taught by viruses

被引：542

作者：

Zinkernagel, RM

机构：

[1] Institute of Experimental Immunology, University of Zurich, CH-8091 Zurich

来源：

SCIENCE | 1996年 / 271卷 / 5246期

关键词：

D O I：

10.1126/science.271.5246.173

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The survival of viruses depends on the survival of susceptible hosts. The vertebrate immune system and viruses have therefore coevolved complementary facets. Evidence from various balanced virus-host relationships illustrates that immunological specificity and memory may best be defined biologically and that the mature immune system does not discriminate between ''self'' and ''nonself.'' Rather, B cells distinguish antigen patterns, whereas T cell responses depend on localization, transport, and kinetics of antigen within lymphatic organs.

引用

页码：173 / 178

页数：6

共 147 条

[1] SELECTION OF GENETIC-VARIANTS OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN SPLEENS OF PERSISTENTLY INFECTED MICE - ROLE IN SUPPRESSION OF CYTO-TOXIC LYMPHOCYTE-T RESPONSE AND VIRAL PERSISTENCE [J].