Estrogen blocks inducible nitric oxide synthase accumulation in LPS-activated microglia cells

被引：53

作者：

Vegeto, E ^{[1
]}

Pollio, G ^{[1
]}

Ciana, P ^{[1
]}

Maggi, A ^{[1
]}

机构：

[1] Ctr MPL, Inst Pharmacol Sci, I-20133 Milan, Italy

来源：

EXPERIMENTAL GERONTOLOGY | 2000年 / 35卷 / 9-10期

关键词：

inflammation; estrogens; Alzheimer's disease; neurodegeneration; nervous system;

D O I：

10.1016/S0531-5565(00)00161-3

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Estrogens are thought to play a protective role against neurodegeneration through a variety of mechanisms including the activation of growth factors and neurotransmitter synthesis, the control of synaptic plasticity and functions, and the blockade of oxidative reactions. We here propose a novel mechanism to explain the neuroprotective effects of estradiol by showing that estrogens may antagonize nitric oxide synthase activity and reduce the accumulation of nitrites and nitrates consequent to various inflammatory stimuli. The potential anti-inflammatory activity of estradiol is analyzed in vitro in cells in culture including primary cultures of microglia and in vivo in a well-known model of inflammation. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：1309 / 1316

页数：8

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