A synergistic approach to optimal stenting -: Directional coronary atherectomy prior to coronary artery stent implantation -: The AtheroLink registry

被引:14
作者
Höpp, HW
Baer, FM
Özbek, C
Kuck, KH
Scheller, B
机构
[1] Univ Cologne, Innere Med Klin 3, D-50924 Cologne, Germany
[2] Univ Saarlandes Kliniken, Homburg, Germany
[3] Allgemeines Krankenhaus St Georg, Hamburg, Germany
关键词
D O I
10.1016/S0735-1097(00)00967-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVES The AtheroLink registry sought to observe the effect of plaque burden reduction by directional coronary atherectomy (DCA) prior to stenting on acute lesion success rate, on the clinical success rate and on the incidence of in-stent restenosis six months after intervention. BACKGROUND Although coronary stenting has reduced restenosis, its effect has been less favorable in complex lesions with a high plaque burden that results from suboptimal stent expansion. Therefore, plaque removal by DCA may improve the results of coronary stenting. METHODS A total of 167 patients with >60% stenosis in a native coronary artery of 2.8 to 4.0 mm in diameter were enrolled in 10 study centers on an intention-to-treat basis. All patients underwent DCA aimed at an optimal result (residual diameter stenosis <20%) followed by stenting. Angiographic follow-up was performed in 120 (71.8%) patients at 5.3 +/- 2.8 months. RESULTS Lesion success was achieved in 164/167 (98.2%) patients, and the clinical success rate was 95.2% (159/167 patients). The overall restenosis rate in the 120 patients with angiographic follow-up nas 10.8% (13/120). incidence of restenosis was lower (8.4%) in patients with optimal stent deployment following DCA compared to patients with a persisting caliber reduction >15% (restenosis rate 15.3.%) and restenosis occurred with a significantly higher frequency (p < 0.04) in distal lesions (37.5%) compared to proximal stenoses (9.0%). CONCLUSIONS This observational multicenter registry points to a potential reduction in restenosis by a synergistic approach of DCA and stenting performed under routinely accessible angiographic guidance. Therefore, multicenter-based randomized clinical trials are clearly warranted to finally clarify the validity of this complex approach versus conventional angioplasty plus stenting. (C) 2000 by the American College of Cardiology.
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页码:1853 / 1859
页数:7
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