Expression of FERM domain including guanine nucleotide exchange factor mRNA in adult rat brain

被引：4

作者：

Madura, T

Yamashita, T

Kubo, T

Taniguchi, M

Kawakita, A

Hosokawa, K

Tohyama, M

机构：

[1] Osaka Univ, Grad Sch Med, Dept Anat & Neurosci, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Dept Plast Surg, Suita, Osaka 5650871, Japan

[3] Japan Sci & Technol Corp, CREST, Kawaguchi, Saitama 3320012, Japan

来源：

MOLECULAR BRAIN RESEARCH | 2003年 / 114卷 / 02期

关键词：

rho guanine nucleotide exchange factor; FERM domain; distribution; brain;

D O I：

10.1016/S0169-328X(03)00166-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

FERM domain including Rho GEF (FIR) belongs to Db1 family of guanine nucleotide exchange factors and specifically activates biochemical pathways specific for Rac1. FIR was shown to regulate neurite remodeling of the embryonic neurons. Here we report a distribution of FIR mRNA in adult rat brain using in situ hybridization. The expression was found all throughout the brain with the most intensive signals in hippocampus, piriform cortex, red nucleus and nuclei of cranial nerves. The signal was predominantly localized in the neuronal cells. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：163 / 167

页数：5

共 23 条

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