MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia

被引：50

作者：

Fan, Jingjing ^{[1
]}

Kou, Xianjuan ^{[1
]}

Yang, Yi ^{[1
]}

Chen, Ning ^{[1
]}

机构：

[1] Wuhan Sports Univ, Hubei Key Lab Exercise Training & Monitoring, Hubei Prov Collaborat Innovat Ctr Exercise & Hlth, Coll Hlth Sci, Wuhan 430079, Peoples R China

来源：

MEDIATORS OF INFLAMMATION | 2016年 / 2016卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

NF-KAPPA-B; APPENDICULAR SKELETAL-MUSCLE; NECROSIS-FACTOR-ALPHA; RESISTANCE EXERCISE; PGC-1-ALPHA EXPRESSION; INFLAMMATORY CYTOKINES; INTERLEUKIN-6; ACTIVATION; PROTEIN; IL-6;

D O I：

10.1155/2016/1438686

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Sarcopenia has been defined as the aging-related disease with the declined mass, strength, and function of skeletal muscle, which is the major cause of frailty and falls in elders. The activation of inflammatory signal pathways due to diseases and aging is suggested to reveal the critical impact on sarcopenia. Several proinflammatory cytokines, especially interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), play crucial roles in modulation of inflammatory signaling pathway during the aging-related loss of skeletal muscle. MicroRNAs (miRNAs) have emerged as the important regulators for the mass and functional maintenance of skeletal muscle through regulating gene expression of proinflammatory cytokines. In this paper, we have systematically discussed regulatory mechanisms of miRNAs for the expression and secretion of inflammatory cytokines during sarcopenia, which will provide some novel targets and therapeutic strategies for controlling aging-related atrophy of skeletal muscle and corresponding chronic inflammatory diseases.

引用

页数：9

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