Inhibitors of the bacterial cell wall biosynthesis enzyme MurD

被引：68

作者：

Gegnas, LD

Waddell, ST

Chabin, RM

Reddy, S

Wong, KK

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Enzymol, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(98)00285-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1643 / 1648

页数：6

共 28 条

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