Impact of chloroquine resistance on malaria mortality

被引:341
作者
Trape, JF
Pison, G
Preziosi, MP
Enel, C
du Lou, AD
Delaunay, V
Samb, B
Lagarde, E
Molez, JF
Simondon, F
机构
[1] ORSTOM, Lab Paludol, Dakar, Senegal
[2] Museum Natl Hist Nat, CNRS, UMR 152, Lab Anthropol Biol, F-75231 Paris, France
[3] ORSTOM, Projet Populat & Sante Niakhar, Dakar, Senegal
来源
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES | 1998年 / 321卷 / 08期
关键词
malaria; Plasmodium falciparum; drug resistance; chloroquine; mortality; Africa;
D O I
10.1016/S0764-4469(98)80009-7
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Over 12 years, from 1984 to 1995, we conducted a prospective study of overall and malaria specific mortality among three rural populations in the Sahel, savanna and forest areas of Senegal. The emergence of chloroquine resistance has been associated with a dramatic increase in malaria mortality in each of the studied populations. After the emergence of chloroquine resistance, the risk of malaria death among children 0-9 years old in the three populations was multiplied by 2.1, 2.5 and 5.5, respectively. This is the first study to document malaria mortality at the community level in Africa before and after the emergence of chloroquine resistance. Findings suggest that the spread of chloroquine resistance has had a dramatic impact on the level of malaria mortality in most epidemiological contexts in tropical Africa. ((C) Academie des sciences / Elsevier, Paris.).
引用
收藏
页码:689 / 697
页数:9
相关论文
共 32 条
  • [1] BEYOND CHLOROQUINE - IMPLICATIONS OF DRUG-RESISTANCE FOR EVALUATING MALARIA THERAPY EFFICACY AND TREATMENT POLICY IN AFRICA
    BLOLAND, PB
    LACKRITZ, EM
    KAZEMBE, PN
    WERE, JBO
    STEKETEE, R
    CAMPBELL, CC
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (04) : 932 - 937
  • [2] Cantrelle P, 1969, ETUDE DEMOGRAPHIQUE
  • [3] Low malaria mortality among children and high rates of Plasmodium falciparum inoculation: A Congolese reality in the 1980s
    Carme, B
    [J]. PARASITOLOGY TODAY, 1996, 12 (05): : 206 - 208
  • [4] CARME B, 1992, TROP MED PARASITOL, V43, P173
  • [5] CHARMOT G, 1991, ANN SOC BELG MED TR, V71, P187
  • [6] DULOU AD, 1994, B WORLD HEALTH ORGAN, V72, P751
  • [7] FOSTER SD, 1991, B WORLD HEALTH ORGAN, V69, P349
  • [8] CHILD-MORTALITY AFTER HIGH-TITER MEASLES-VACCINES - PROSPECTIVE-STUDY IN SENEGAL
    GARENNE, M
    LEROY, O
    BEAU, JP
    SENE, I
    [J]. LANCET, 1991, 338 (8772) : 903 - 907
  • [9] GARENNE M, 1986, ASSESSING PROBABLE C
  • [10] GREENBERG AE, 1989, B WORLD HEALTH ORGAN, V67, P189