A biotechnological perspective on the application of iron oxide magnetic colloids modified with polysaccharides

被引：259

作者：

Dias, A. M. G. C. ^{[1
]}

Hussain, A. ^{[1
]}

Marcos, A. S. ^{[1
]}

Roque, A. C. A. ^{[1
]}

机构：

[1] Univ Nova Lisboa, Dept Quim, Fac Ciencias & Tecnol, REQUIMTE, P-2829516 Caparica, Portugal

来源：

BIOTECHNOLOGY ADVANCES | 2011年 / 29卷 / 01期

关键词：

Magnetic nanoparticles; Iron oxide; Polysaccharides; Biotechnology; Biomedical; HEMATOPOIETIC PROGENITOR CELLS; IN-SITU SYNTHESIS; ULTRASENSITIVE DETECTION; AFFINITY LIGANDS; ARSENIC REMOVAL; NANOPARTICLES; GUM; CHITOSAN; ALGINATE; PURIFICATION;

D O I：

10.1016/j.biotechadv.2010.10.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Iron oxide magnetic nanoparticles (MNPs) alone are suitable for a broad spectrum of applications, but the low stability and heterogeneous size distribution in aqueous medium represent major setbacks. These setbacks can however be reduced or diminished through the coating of MNPs with various polymers, especially biopolymers such as polysaccharides. Polysaccharides are biocompatible, non-toxic and renewable; in addition, they possess chemical groups that permit further functionalization of the MNPs. Multifunctional entities can be created through decoration with specific molecules e.g. proteins, peptides, drugs, antibodies, biomimetic ligands, transfection agents, cells, and other ligands. This development opens a whole range of applications for iron oxide nanoparticles. In this review the properties of magnetic structures composed of MNPs and several polysaccharides (Agarose, Alginate, Carrageenan, Chitosan, Dextran, Heparin, Gum Arabic, Pullulan and Starch) will be discussed, in view of their recent and future biomedical and biotechnological applications. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：142 / 155

页数：14

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