SRprises along a messenger's journey

被引：227

作者：

Huang, YQ

Steitz, JA

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biophys & Biochem, New Haven, CT 06536 USA

[2] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA

来源：

MOLECULAR CELL | 2005年 / 17卷 / 05期

关键词：

D O I：

10.1016/j.molcel.2005.02.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SR (serine/arginine-rich) proteins were originally identified as essential splicing factors. Recent work, however, has implicated these proteins in numerous additional steps of mRNA metabolism, including nuclear export, RNA stability, mRNA quality control, and translation.

引用

页码：613 / 615

页数：3

共 16 条

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Lejeune, F
Stévenin, J
[J]. PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 78, 2004, 78 : 37 - 88
[2] A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm
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[3] Nucleocytoplasmic transport: Integrating mRNA production and turnover with export through the nuclear pore
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[J]. RNA, 2001, 7 (02) : 302 - 313
[5] A molecular link between SR protein dephosphorylation and mRNA export
Huang, YQ
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[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) : 9666 - 9670
[6] SR splicing factors serve as adapter proteins for TAP-dependent mRNA export
Huang, YQ
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Stévenin, J
Steitz, JA
[J]. MOLECULAR CELL, 2003, 11 (03) : 837 - 843
[7] Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins
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Tarn, WY
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (30) : 31745 - 31749
[8] A human importin-β family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins
Lai, MC
Lin, RI
Huang, SY
Tsai, CW
Tarn, WY
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (11) : 7950 - 7957
[9] Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2:: a novel function for SR proteins
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Prasad, J
Kashima, T
Gustafson, J
Manley, JL
Lafyatis, R
[J]. GENES & DEVELOPMENT, 2002, 16 (05) : 594 - 607
[10] Nonsense-mediated mRNA decay: Splicing, translation and mRNP dynamics
Maquat, LE
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (02) : 89 - 99

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