Gabapentin - Antiepileptic mechanism of action

被引：45

作者：

Kelly, KM ^{[1
]}

机构：

[1] Allegheny Univ Hlth Sci, Neurosci Res Ctr, Pittsburgh, PA 15212 USA

来源：

NEUROPSYCHOBIOLOGY | 1998年 / 38卷 / 03期

关键词：

gabapentin; mechanism of action; antiepileptic drug; GABA; ion channels; receptors;

D O I：

10.1159/000026529

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gabapentin is an antiepileptic drug used in the treatment of partial and generalized tonic-clonic seizures. Its antiepileptic mechanism of action is not known. The transport of gabapentin across membranes and its demonstrated effects on voltage-gated ion channels (sodium, calcium), presynaptic mechanisms that can enhance GABAergic inhibition, and ligand-gated ion channels (GABA receptors and glutamate receptors) are reviewed.

引用

页码：139 / 144

页数：6

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