Poly(lactic acid) (PLA) based nanocomposites - a novel way of drug-releasing

被引：103

作者：

Chen, Chen ^{[1
]}

Lv, Gang ^{[1
]}

Pan, Chao ^{[1
]}

Song, Min ^{[1
]}

Wu, Chunhui ^{[1
]}

Guo, Dadong ^{[1
]}

Wang, Xuemei ^{[1
]}

Chen, Baoan ^{[2
]}

Gu, Zhongze ^{[1
]}

机构：

[1] SE Univ, State Key Lab Bioelect, Chien Shiung Wu Lab, Nanjing 210096, Peoples R China

[2] SE Univ, Sch Clin Med, Zhongda Hosp, Nanjing 210096, Peoples R China

来源：

BIOMEDICAL MATERIALS | 2007年 / 2卷 / 04期

关键词：

D O I：

10.1088/1748-6041/2/4/L01

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this communication, poly( lactic acid) nanofibers have been fabricated by electrospinning and then poly( lactic acid) (PLA) based nanocomposites have been prepared by accumulating anticancer drug daunorubicin on PLA nanofibers combined with TiO2 nanoparticles. Our atomic force microscopy (AFM) and laser-scanning confocal microscope (LSCM) studies demonstrate that the respective drug molecules could be readily self-assembled on the surface of the blends of nano-TiO2 with PLA polymer nanocomposites, which could further efficiently facilitate the drug permeation and accumulation on the target leukemia K562 cells. Besides, the respective new nanocomposites have good biocompatibility, ease of surface chemistry modification and very high surface area, which may afford the possibility for their promising application in pharmacology and biomedical engineering areas.

引用

页码：L1 / L4

页数：4

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