Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men:: British Women's Heart and Health Study and Caerphilly cohorts

被引：27

作者：

Ebrahim, Shah ^{[1
]}

Lawlor, Debbie A. ^{[2
]}

Ben Shlomo, Yoav ^{[2
]}

Timpson, Nicholas ^{[2
]}

Harbord, Roger ^{[2
]}

Christensen, Mikkel ^{[3
]}

Baban, Jamil ^{[3
]}

Kiessling, Matt ^{[3
]}

Day, Ian ^{[3
]}

Gaunt, Tom ^{[3
]}

Smith, George Davey ^{[2
]}

机构：

[1] London Sch Hyg & Trop Med, Dept Epidemiol & Populat Hlth, London WC1E 7HT, England

[2] Univ Bristol, Dept Social Med, Bristol, Avon, England

[3] Univ Southampton, Sch Med, Div Human Genet, Southampton SO9 5NH, Hants, England

来源：

ATHEROSCLEROSIS | 2008年 / 196卷 / 02期

基金：

英国医学研究理事会;

关键词：

alcohol; ADH1C polymorphisms; HDL-cholesterol; coronary heart disease;

D O I：

10.1016/j.atherosclerosis.2007.02.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The alcohol dehydrogenase 1C gene (ADH1C) gamma 2 gamma 2 variant reportedly interacts with moderate alcohol consumption to increase HDL-cholesterol levels and reduce coronary heart disease (CHD). We undertook replication studies in two large population cohorts of women and men. 3234 women and 1313 men with relevant genotypic and phenotypic data from two prospective population cohorts were genotyped for ADH1C variants. No association was found between ADH1C variants and HDL-cholesterol, blood pressure or incident CHD, although ADH1C was associated with alcohol consumption. There was no evidence of interactions between ADH1C variants and moderate alcohol intake on HDL-cholesterol, blood pressure or CHD incidence. Life-long women abstainers had adverse risk factor profiles. Our findings do not support the hypothesis that ADH1C variants are associated with CHD risk in people who drink moderately. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：871 / 878

页数：8

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