Differential tolerance to morphine's immunomodulatory effects following continuous administration

被引：13

作者：

West, JP ^{[1
]}

Dykstra, LA

Lysle, DT

机构：

[1] Univ N Carolina, Curriculum Neurobiol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA

来源：

DRUG AND ALCOHOL DEPENDENCE | 1998年 / 53卷 / 01期

关键词：

tolerance; morphine; gamma-interferon; natural killer; con-A; TSST-1; continuous infusion;

D O I：

10.1016/S0376-8716(98)00109-4

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Rats were continuously infused with either morphine or saline via an osmotic minipump for 20 consecutive days. Effects on immune status were assessed on the twentieth day of the chronic administration period following a bolus injection of morphine administered 1 h prior to sacrifice. The morphine injection suppressed measures of splenic natural killer (NK) cell activity, mitogen-stimulated T-cell proliferation, and gamma-interferon (IFN) production in rats that received saline via the minipump. In rats that received chronic morphine via the minipump, the morphine injection also suppressed mitogen-stimulated splenocyte proliferation and gamma-IFN production but did not suppress NK cell activity. These data indicate that chronic morphine administration via osmotic minipumps leads to differential tolerance to the immunomodulatory effects of morphine. These findings support previous results indicating differential tolerance development within the immune system following chronic morphine administration via the drinking water. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：31 / 38

页数：8

共 38 条

[1]

AYESTA FJ, 1989, J PHARMACOL EXP THER, V250, P371

[2] MORPHINE-INDUCED IMMUNOMODULATION IS NOT RELATED TO SERUM MORPHINE CONCENTRATIONS [J].

BRYANT, HU ;

YOBURN, BC ;

INTURRISI, CE ;

BERNTON, EW ;

HOLADAY, JW .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 149 (1-2) :165-169

[3]

BRYANT HU, 1988, J PHARMACOL EXP THER, V245, P913

[4]

BRYANT HU, 1990, J PHARMACOL EXP THER, V255, P410

[5]

BUSSIERE JL, 1993, J PHARMACOL EXP THER, V264, P591

[6]

CARR DJJ, 1993, J PHARMACOL EXP THER, V267, P9

[7]

CHAO CC, 1990, J PHARMACOL EXP THER, V252, P605

[8]

DEJARLAIS D, 1988, REV INFECT DIS, V10, P151

[9]

DONAHOE RM, 1993, ADV EXP MED BIOL, V335, P21

[10]

EISENSTEIN TK, 1990, ANN NY ACAD SCI, V594, P377

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