Junction-forming aquaporins

被引：64

作者：

Engel, Andreas ^{[2
]}

Fujiyoshi, Yoshinori ^{[3
]}

Gonen, Tamir ^{[4
]}

Walz, Thomas ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Univ Basel, Maurice E Mueller Inst, Biozentrum, CH-4056 Basel, Switzerland

[3] Kyoto Univ, Fac Sci, Dept Biophys, Sakyo Ku, Kyoto 6068502, Japan

[4] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2008年 / 18卷 / 02期

关键词：

D O I：

10.1016/j.sbi.2007.11.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aquaporins (AQPs) are a family of ubiquitous membrane channels that conduct water and solutes across membranes. This review focuses on AQP0 and AQP4, which in addition to forming water channels also appear to play a role in cell adhesion. We discuss the recently determined structures of the membrane junctions mediated by these two AQPs, the mechanisms that regulate junction formation, and evidence that supports a role for AQP0 and AQP4 in cell adhesion.

引用

页码：229 / 235

页数：7

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