Glycosyltransferase-catalyzed synthesis of thiooligosaccharides

被引：45

作者：

Rich, JR ^{[1
]}

Szpacenko, A ^{[1
]}

Palcic, MM ^{[1
]}

Bundle, DR ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Alberta Ingenu Ctr Carbohydrate Sci, Edmonton, AB T6G 2G2, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 05期

关键词：

enzyme catalysis; glycosylation; oligosaccharides; thiooligosaccharides;

D O I：

10.1002/anie.200352606

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An alternative to chemical synthesis: thiooligosaccharides can be prepared from appropriate carbohydrate thiols and sugar nucleotide donors by incubation with glycosyltransferases. The products of these reactions are stable towards glycosylhydrolases and may serve as antigens with extended in vivo availability.

引用

页码：613 / 615

页数：3

共 41 条

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