siRNA technology

被引：40

作者：

Schütze, N ^{[1
]}

机构：

[1] Orthopaed Univ Hosp, D-97074 Wurzburg, Germany

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2004年 / 213卷 / 02期

关键词：

RNA interference; siRNA; functional genomics; gene silencing;

D O I：

10.1016/j.mce.2003.10.078

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

RNA interference (RNAi) represents a mechanism invented by nature to protect the genome. In the past few years the field has emerged at a surprisingly high pace. The underlying molecular mechanism of gene silencing provides us with short interfering RNAs (siRNAs) which allows to target any gene with high specificity and efficiency. siRNAs can now be obtained in various ways allowing for numerous in vitro and in vivo applications. Successful knock-downs of disease-related genes indicate that siRNAs open the door for novel therapeutic procedures. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：115 / 119

页数：5

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