Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar

被引：67

作者：

Imwong, Mallika ^{[1
]}

Pukrittayakamee, Sasithon ^{[1
,3
]}

Pongtavornpinyo, Wirichada ^{[1
]}

Nakeesathit, Supatchara ^{[1
]}

Nair, Shalini ^{[2
]}

Newton, Paul

Nosten, Francois ^{[1
,4
,5
]}

Anderson, Timothy J. C. ^{[2
]}

Dondorp, Arjen ^{[1
,5
]}

Day, Nicholas P. J. ^{[1
,5
]}

White, Nicholas J. ^{[1
,5
]}

机构：

[1] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok 10400, Thailand

[2] SW Fdn Biomed Res, San Antonio, TX 78284 USA

[3] Royal Inst Grand Palace, Bangkok, Thailand

[4] Shoklo Malaria Res Unit, Mae Sot, Tak, Thailand

[5] Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/AAC.01459-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.

引用

收藏

页码：2657 / 2659

页数：3

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