Triterpene saponins from the roots of Dipsacus asper and their protective effects against the Aβ25-35 induced cytotoxicity in PC12 cells

被引：22

作者：

Ji, De ^{[1
]}

Wu, Yue ^{[1
]}

Zhang, Bin ^{[1
]}

Zhang, Chun-Feng ^{[1
]}

Yang, Zhong-Lin ^{[1
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Prod & Funct, Minist Educ, Nanjing 210009, Peoples R China

来源：

FITOTERAPIA | 2012年 / 83卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Dipsacus asper; Triterpene saponin; Asperosaponin A-C; Amyloid beta; Cytotoxic activity; SALVIANOLIC-ACID-B; ASPEROSAPONIN VI; STRUCTURAL DETERMINATION; WALL; DERIVATIVES; ANTIOXIDANT; APOPTOSIS;

D O I：

10.1016/j.fitote.2012.03.004

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Three new triterpene saponins, named asperosaponin A-C (1-3), together with seven known triterpene saponins (4-10) were isolated from the roots of Dipsacus asper. The structures of compounds 1-3 were elucidated on the basis of detailed spectroscopic analysis and chemical methods. Compounds 1-3, 6-10 had significantly protective effects in PC12 cells against the A beta(25-35) induced cytotoxicity. All the compounds isolated showed no cytotoxic activity against three human cancer cell lines, A-549, Bel-7402 and BGC-823. (C) 2012 Elsevier B.V. All rights reserved.

引用

收藏

页码：843 / 848

页数：6

相关论文

共 33 条

[1]

Cytotoxic saponins from the root of Dipsacus asper Wall [J].

Hung, TM ;

Jin, W ;

Thuong, PT ;

Song, KS ;

Seong, YH ;

Bae, K .

ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (09) :1053-1056

[2]

Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall [J].

Hung, Tran Manh ;

Na, MinKyun ;

Thuong, Phuong Thien ;

Su, Nguyen Duy ;

Sok, DaiEun ;

Song, Kyung Sik ;

Seong, Yeon Hee ;

Bae, KiHwan .

JOURNAL OF ETHNOPHARMACOLOGY, 2006, 108 (02) :188-192

[3]

Apoptosis-inducing Effect of Akebia Saponin D from the Roots of Dipsacus asper Wall in U937 Cells [J].

Jeong, Seung-Il ;

Zhou, Beng ;

Bae, Jin-Beom ;

Kim, Nam-Seok ;

Kim, Sun-Geun ;

Kwon, Jin ;

Kim, Dae-Keun ;

Shin, Tae-Yong ;

Jeon, Hoon ;

Lim, Jong-Phil ;

Kim, Hongjun ;

Kim, Ho Kyoung ;

Oh, Chan-Ho .

ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (11) :1399-1404

[4]

TRITERPENE GLYCOSIDES FROM THE ROOTS OF DIPSACUS-ASPER [J].

JUNG, KY ;

DO, JC ;

SON, KH .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (11) :1912-1916

[5]

Effects of the Dichloromethane Fraction of Dipsaci Radix on the Osteoblastic Differentiation of Human Alveolar Bone Marrow-Derived Mesenchymal Stem Cells [J].

Kim, Beom-Su ;

Kim, Yoon-Chul ;

Zadeh, Homa ;

Park, Yoon-Jeong ;

Pi, Sung-Hee ;

Shin, Hyung-Shik ;

You, Hyung-Keun .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2011, 75 (01) :13-19

[6]

KOUNO I, 1990, PHYTOCHEMISTRY, V29, P338, DOI 10.1016/0031-9422(90)89068-K

[7]

Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways [J].

Li, Chunmei ;

Tian, Jingwei ;

Li, Guisheng ;

Jiang, Wanglin ;

Xing, Yanli ;

Hou, Jian ;

Zhu, Haibo ;

Xu, Hong ;

Zhang, Guanbo ;

Liu, Zhifeng ;

Ye, Zuguang .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2010, 649 (1-3) :100-107

[8]

Protective roles of Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall on acute myocardial infarction in rats [J].

Li, Chunmei ;

Liu, Zhifeng ;

Tian, Jingwei ;

Li, Guisheng ;

Jiang, Wanglin ;

Zhang, Guanbo ;

Chen, Fangfang ;

Lin, Peiyan ;

Ye, Zuguang .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2010, 627 (1-3) :235-241

[9]

Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents Aβ25-35-induced reduction in BPRP in PC12 cells [J].

Lin, Yan-Hua ;

Liu, Ai-Hua ;

Wu, Hong-Li ;

Westenbroek, Christel ;

Song, Qian-Liu ;

Yu, He-Ming ;

Ter Horst, Gert J. ;

Li, Xue-Jun .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 348 (02) :593-599

[10]

Protection of PC12 cells from hydrogen peroxide-induced cytotoxicity by salvianolic acid B, a new compound isolated from Radix Salviae miltiorrhizae [J].

Liu, Chang-Suo ;

Chen, Nal-Hong ;

Zhang, Jun-Tian .

PHYTOMEDICINE, 2007, 14 (7-8) :492-497

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