Cyclooxygenase-2 in the hippocampus is up-regulated in Alzheimer's disease but not in variant Alzheimer's disease with cotton wool plaques in humans

被引：19

作者：

Yokota, O ^{[1
]}

Terada, S

Ishizu, H

Ishihara, T

Ujike, H

Nakashima, H

Nakashima, Y

Kugo, A

Checler, F

Kuroda, S

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Neuropsychiat, Okayama 7008558, Japan

[2] Zikei Inst Psychiat, Dept Lab Med, Okayama 7028508, Japan

[3] Sanyo Hosp, Okayama 7028006, Japan

[4] CNRS, Inst Pharmacol Mol & Cellulaire, UMR6097, F-06560 Valbonne, France

来源：

NEUROSCIENCE LETTERS | 2003年 / 343卷 / 03期

关键词：

Alzheimer's disease; cyclooxygenase-2; cotton wool plaque; hippocampus; inflammation; non-steroidal anti-inflammatory drugs;

D O I：

10.1016/S0304-3940(03)00339-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, and neuron densities in the CA1-4 of the hippocampus in three cases of Alzheimer's disease with cotton wool plaques (CWP-AD), 17 cases of typical Alzheimer's disease without CWPs (tAD), and 26 normal controls. Cyclooxygenase-2 expression was significantly increased in all of the CA1-4 in tAD, but not in any subdivision in CWP-AD, compared with controls. Cyclooxygenase-2 expression in tAD was also significantly up-regulated compared with that in CWP-AD in all subdivisions. Furthermore, neuron density in the hippocampus was not significantly reduced in CWP-AD cases compared with controls despite remarkable intra- and extraneuronal Abetabeta deposition. These findings suggest that unknown factors besides Abeta deposition are necessary for the cyclooxygenase-2 up-regulation and neurodegeneration in Alzheimer's disease. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：175 / 179

页数：5

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