Total synthesis of cribrostatin IV: Fine-tuning the character of an amide bond by remote control

被引：95

作者：

Chan, C

Heid, R

Zheng, SP

Guo, JS

Zhou, BS

Furuuchi, T

Danishefsky, SJ

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

[2] Mem Sloan Kettering Canc Ctr, Bioorgan Chem Lab, New York, NY 10021 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 13期

关键词：

D O I：

10.1021/ja050203t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the enantioselective total synthesis of cribrostatin IV (1). Key features of this synthesis involve the convergent coupling of two highly functionalized homochiral components followed by a lynchpin" Mannich cyclization to establish the pentacyclic core (cf. 19 → 20). Copyright © 2005 American Chemical Society."

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页码：4596 / 4598

页数：3

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